Wednesday, March 13, 2019

#62 the past biting back?, 2 useful words, a bit more on genetics & personality, bereavement effect on health




Good morning! 

            In the course of an email exchange on another topic, a friend wrote to me with an insightful observation.  "I am torn over the black face fiasco in Virginia - the 80s were a time of not much sensitivity. It was a poor choice, to be sure, but to blow up the careers of anybody who did something like that seems over the top too. It makes me think that 15-20 years from now as this current generation of people that have thousands more photos and videos of themselves move into adult and high powered jobs - how are they ever going to get past something they did in their youth? Aren't we potentially limiting the available pool of decent public figures if you have to have people that were so socially recluse they never left their house, thus never offended anybody - or were rich and powerful enough to figure out how to delete all electronic images of themselves?"

Setting aside the case of the accusations against the Lt. Governor, which are different and may involve criminal actions, it does seem to me that people can grow in their views and attitudes over 35 years.  I certainly have.

            As for what Millennials will face, the Washington Post had an article a couple of days after my friend sent the message.  Maya Kosoff, the author, argues that her generation "grew up with the expectation of constant surveillance."  Her parents were like me:  "Soon after I joined Facebook as a high school freshman in 2006, I received a stern warning from my parents and my school's guidance counselors:  Everything you post on the Internet is there forever.  If you want to eventually get into college and have a job, you should be careful what you put online."  Some say that millennials, having recorded much of their life, will surely encounter difficulties when an unsavory or unwise event surfaces.

            Kosoff thinks not. 

Our parents needn't have worried. We've always known more about managing appearances than older generations ever will.  Having grown up with the Internet, we knew that the things we put online were potentially permanent and that, inevitably, someone was watching. We internalized its omnipresent logic of surveillance, crafting our behavior and our virtual selves in accordance with the knowledge that someone, somewhere might one day judge us. Far from dooming us, our comfort with social media might make us better political candidates.

She, however, was and is highly savvy about the implications of what is posted online.  I doubt that all or even most millennials are that perceptive. 

She even goes one step further.  "Millennials are mocked for taking selfies or posting pictures of our meals, but those habits speak to our interest in crafting an image of our lives for the people who are already watching — and sometimes waiting to pounce."  To what extent, do you imagine, we all "craft an image," even if subconsciously or unintentionally, when we use social media?  Kosoff also points out that some recent social media are built to disappear; after 24 hours, posts on Snapchat and Instagram vanish.  There is also widespread understanding that certain social media companies misuse or abuse personal data drawn from posts, so people are wary about posting much substance and deleting what went before.

            She concludes:  "the common wisdom that constant digital surveillance will make it harder for us to run for office looks dubious. Instead, growing up with an understanding of the Internet's immutability may make us more scandal-proof than our predecessors."

            I guess we'll see.

* * *

In the "love of words" category, here are two that are timely for many.  Technically they apply to birds, but as in the evolution of all language, their use has spread.  One is "nidifugous" (ny-DIF-yuh-guhs), which is "well-developed and able to leave the nest soon after hatching."  Its opposite is "nidicolous" (remaining with parents for a long time after birth).   So, as the author of A.Word.A.Day points out, "if your adult child suggests living in your basement, you could simply say, 'Don't be nidicolous!"

* * *

            A brief return to genetics and personality traits.  My good friend (and Professor of Biology at the University of Oregon) Nathan Tublitz wrote to me in response to my short disquisition on personality and genetics.  He offered three amplifications that help to understand the phenomena.

1) THE GENETIC COMPONENT OF HUMAN TRAITS IS VARIABLE DEPENDING ON THE SPECIFIC TRAIT. All human traits, including components of personality, appear to have a genetic component. What is important to note here is that the relative impact of genetics on specific traits is highly variable, ranging from very minor to 100% (the latter in the case of eye color). Because of this variability and because we have not yet identified the genes involved in individual personality traits, it is not yet possible to draw firm conclusions about the impact of genetics on specific traits. Research that purports to draw such conclusions has to be viewed as highly speculative.

2) A 50% GENETIC COMPONENT OF A TRAIT MEANS THERE IS A 50% ENVIRONMENTAL COMPONENT TOO.  A 50% genetic contribution to an individual personality trait implies that 50% of that trait is shaped by environmental factors (which to us biologists, also means the internal environment including hormones). It is worth noting the obvious but not often stated point that the environmental 50% will also have a substantial impact on a trait.

3) GENES  ARE NOT STATIC. The effects of individual genes are neither binary nor static throughout the lifespan of an individual. Some genes only turn on once (for a specific period of time). However many genes turn on and off multiple times during the lifetime of an individual, and the downstream effects of an individual gene is not always the same each time it is activated. Moreover, the triggers for gene activation/inhibition are often environmental and may be different each time a gene is activated/inhibited. Thus the genetic contribution to specific personality traits (and behavior) is almost certainly variable throughout our lifetimes and not fixed as is often assumed.

Those who want simple answers to questions of human personality and behavior will undoubtedly be disappointed by these points. However those of us who study these issues continue to be fascinated and indeed awed by the enormously complex interactions between genetic, neural and environmental mechanisms that underlie behavior of all organisms including humans.

            Thank you, Nathan.  I learned from this!

* * *

            Because, for obvious reasons, bereavement has been on my mind in recent months, I found this pertinent (and troubling)—and it is or will be an issue for all of us at some point in our lives, especially as those of us in the Baby Boomer cohort reach old age.  There was recently an interview in nextavenue with Professor (and M.D.) Toni Miles, director of the Institute of Gerontology at the University of Georgia.  On reflection, I realized the evidence she presented is not surprising, but it is nonetheless a cause for concern.

            The gist of the research findings is that "a significant loss is deadly serious, putting the grieving at higher risk for serious health problems, and even their own premature death."  Miles said that "critical losses are destabilizing and accumulate over time. The death of a significant loved one — by that I mean a parent, spouse, sibling or child — increases your own risk of dying."  She reported that she was not referring to an elderly couple where one dies shortly after the other (aka, in some cases, takotsubo cardiomyopathy or "broken heart" syndrome); she used data from those 50 years old or older who "lost someone close in the last twenty-four months. At a population level, those people are two times more likely to die over the course of a lifetime than someone without that loss."  (Either she spoke loosely or the person recording the interview was careless with language.  Everyone is likely to die over the course of a lifetime!  To put it correctly, presumably she meant " . . . two times more likely to die early or prematurely over the course of a lifetime. . . .")

            The greatest impact on life expectancy is within the first two years after the death of someone close.  More frightening, "the research also shows that the younger you are when you lose someone important to you, the worse it is for your health. The elevated mortality risk for children who lose a parent goes up fivefold."  Niles also reports that "in our models, losing a child, even an adult child, statistically carries a high risk of morbidity."  So far I'm still here, but given these findings, I do wonder if Krystin's death will have a long-term effect on the length of my life.  Unfortunately, it probably will:

            [Interviewer]  It sounds like time, in fact, does not heal these wounds.

[Niles]  That's true. The risk never goes away; it does not return to the expected level of the general population that has not experienced such a loss. Even when you adjust for age, the risk stays higher. When we measure this at a population level, we believe that five percent of the deaths that happen in a year are attributable to a loss; by that I mean, they might not have died if they didn't have this loss in their background.

Yikes.  But I do have a question about the data Dr. Niles presents.  In the normal course of events, parents die before their children, and statistically when the children are adults.  *All* of us lose parents (unless we predecease them, but set that case aside).  So that's one major loss we all face.  Many lose a spouse; many lose siblings.  Some lose children.  Are not the effects of those losses on the survivors already built into life-expectancy statistics?  If so, how does the effect of one such loss in one person's life mesh with the fact that life expectancy is already affected by these losses?  I can't quite get my head around how those two facts interact.  (I know, it's population statistics versus the experience of an individual.  Even so. . . .)

            Needless to say, if my life expectancy was 85 (a number I made up) before Krystin died, and it's now lower, I am not thrilled.

In a book review of Advice for the Dying (and Those Who Love Them): A Practical Perspective on Death, by Sallie Tisdale, the reviewer quotes Tisdale to the same effect that Niles did:

After the death . . . there are the survivors and their grief. Writes Tisdale:

"Grief lives in the body. MRI studies show that a grieving brain has a pattern unlike other emotions. Most of the time, an emotion lights up parts of the brain, but grief is distributed everywhere, into areas associated with memory, metabolism, visual imagery, and more. Grief can make you sick; it can be brutal, even deadly."

This has been shown by studies into the effects of bereavement on physical and mental well-being. Research done in the Karolinska Institutet in Sweden has shown that bereavement is correlated with adverse health outcomes like self-harm, hip fracture and unplanned hospitalisation. Similarly, results from the latest wave of the Irish Longitudinal Study on Ageing, run out of Trinity College, showed widowhood a greater predictor of frailty in older adults than being single or separated.

            Niles argues this is a public health issue that should receive attention, with a focus on ways to mitigate the impact of loss.  I suppose, but I'm not sure what anyone could do or say that would lessen the impact of Krystin's death on me (or her mother or brother or Kathy).

            I have another reservation—and this reflects a personal view rather than any data—is that (for me) the age and medical condition of the person who died affects the extent and duration of grief.  My cousin Mae lived to 94, had a full and active life, was ailing and unhappy the last year or so and was ready to go.  I don't know that my dad at 83 was ready to go but he'd had a full and active life and got to see all seven of his grandchildren at least reach their teenage years (and was headed for a decline from Parkinson's that he would not have liked).  My mother at age 62 was definitely *not* ready to go, and certainly Krystin was not.  In the latter two cases I grieve deeply; in the former two, less so.  It would be enlightening to parse Dr. Niles's data to learn if the impact of the loss varies with the age and condition of the decedent.  It may be that there is wide variation in effect, moderated by age and medical status.

* * *

            I sometimes wonder if I am guilty of omphaloskepsis when I write these emails.  I hope not.

            On that amusing lexicographical note, I wish you well for the week.

-- Gary 


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