Thursday, February 8, 2018

#34 grads and jobs, Epicurus, pain and swearing, DARPA, sugar & mental health & the ketogenic diet




Good morning! 

            A friend wrote back to comment on the finding that all net new jobs are going to college graduates and in response to my rhetorical question about whether college graduate are even taking the jobs that don't require a degree. 

I don't think my son's job required a degree.  Others there did not have one. But it certainly didn't hurt—despite it being history and political science at a mortgage lender.  He stayed and moved up the ladder a bit, which the non-degreed people mostly didn't, I think.

He makes a good point.  I can imagine that even if hired into a job that doesn't require a degree, those with the degree may have the option to move up; those without will likely not—or at least not move up very far.  Unfortunately, this isn't the case for Elliott in his current position, taking care of research animals.  You don't go up that ladder without a degree in biology or veterinary medicine—credentials Elliott has no intention of seeking.

            My friend wrote about a related point.

It is the "gig economy" that worries me.  No security or benefits or ability to resist exploitation.  But there is a freedom to it that many enjoy—at least while they are young.  I liked "permanent" employment, though the permanence eventually ended as my employer changed its business.

            The gig economy is indeed a threat to social well-being, in my opinion.  You don't make enough money to save anything for education or retirement, and may not make enough to pay for the groceries and the rent.  It is precisely for those reasons that Elliott opted for a job totally unrelated to his degree or interests:  it has great health care benefits and he's in a retirement plan.  Now he just has to figure out how to keep the benefits but move to a position where he can advance and perhaps even make use of his artistic talents.  But at least the former!

* * *

            Anthony Gottlieb, in 1843, the magazine of the Economist, asks, "Where is a hedonist to look for his heroes?"  [Gottlieb speaking for himself, so "his."]  It's not a dumb question for people who view life and the universe in entirely physical terms and entertain deep skepticism about any afterlife.  If this is the only life we have, then we should enjoy it to the full extent possible in our own circumstances—we must be hedonists.

            Gottlieb observes that the world's religions are not enthusiastic about indulging in the pleasures of life.  The three Abrahamic religions, in his words, "are more interested in pleasing God than in pleasing man" and even Judaism, more tolerant of pleasure than the other two, "keeps a wary eye open for recriminations from above."  Asian religions are not much better. 

One of history's major advocates for being a hedonist was Epicurus.  Very few of his writings survive; most of what is attributed to him came from commentators.  As sometimes happens in the evolution of language, Epicurus gets a bad rap from his adjective, epicurean:  "fond of or adapted to luxury or indulgence in sensual pleasures; having luxurious tastes or habits, especially in eating and drinking."  The Church condemned his views through the Middle Ages.

As also sometimes happens in the evolution of language, the characterization of Epicurus was simply wrong, as best scholars can tell from the evidence.  There is much to admire about him.  He was likely to be condemned from many quarters, apart from the charge of gluttony, because he wasn't religious, and indeed argued that "the world consists . . . of tiny material atoms careering around in space until they randomly collide and form the things and creatures we see.  When our atoms disperse and we die, that is the end of us."  Death is not to be feared because all pain is gone.  He also maintained that the goal in life should be to avoid pain and find pleasure; what causes pain is evil and what leads to pleasure is good.  Contrary to what many understand, Epicurus did not argue for the unrestricted pursuit of pleasure; what people should seek is an absence of pain, which will lead to a satisfactory and happy life.  He also insisted that nothing should be believed that cannot be observed, tested, or deduced logically.  (I'm not sure how, given that, he got to an atomic theory of matter.)

The aim of philosophy, Epicurus maintained, is to make people happy, and one of its biggest tasks is to quieten the unnecessary terrors caused by religion.  In particular, it was crucial to overcome the fear of death and of an unpleasant afterlife.  "All good and evil lie in sensation, whereas death is the absence of sensation," wrote Epicurus in a letter.  "Hence a correct understanding that death is nothing to us makes the mortality of life enjoyable, not by adding infinite time, but by ridding us of the desire for immortality."

Epicurus maintained that one should also seek to minimize harm or pain in others as well, as a path to happiness.

I don't buy into the blanket claim that religions cause "unnecessary terrors."  Some parts of some belief systems do so, but I know of too many people who practice their religion without fear and without inciting fear in others.  I may not agree with the premises but I can't persuasively criticize the approach to life that they embody.

As for food, according to Gottlieb (and I think he's correct)

Epicurus did once say that in order to lead a happy life, one needs first of all to be fed.  This was easy to quote out of context, and his reputation as a glutton is probably based on little more than that.  In fact, Epicurus condemned all forms of over-indulgence, and recommended a simple diet. [And] for Epicurus, tranquillity was the ultimate delight. . . .  That is why the real Epicurus . . . denounced the rapidly rotting fruits of dissipation and excess.  The constant pursuit of intense pleasures will in fact backfire, according to Epicurus, because it leads to the psychological hell of enslavement to unsatisfiable appetites.  The would-be hedonist must take care to ensure that the pain of overreaching desire does not ruin his peace of mind and thereby defeat his original aim of securing a balance of pleasure over pain.

            Epicurus is my kind of philosopher.  Avoid pain and suffering (my own and try to prevent it befalling others) and seek pleasure in moderation.  Eat well (especially meals prepared by others).  Have a beer or a glass of wine.

            So have a good lunch today and think of Epicurus.

* * *

According to Emma Byrnes in The Scientist, "screaming obscenities when you stub your toe makes perfect biological sense."  In an article titled "Why Swearing and Pain Go Hand in Hand," she reports on research that she and others have done (and she's also written a book on the subject).  People (in experimental settings) who swear when in pain can tolerate pain longer and later report feeling less pain than those who were not allowed to swear.  Her initial research was in a bar late at night, but the results paralleled more rigorous university-based research:  people could keep their hand in ice water longer if they could say "shit" or something similar. 

            Byrnes observes that "pain is not a purely neurological phenomenon. . . .  peripheral sensory neurons give you information about a stimulus, but the way you process that pain is as much psychologically constructed as it is neurologically formed.  Our anticipation of pain, our gender roles and social expectations, even whether we're feeling lonely or sad, all change the way we feel pain." 

            In addition, subsequent research suggests that "minced oaths"—the phrases we use in polite company when we really want to utter an epithet or obscenity—don't work as well as the curse itself.  "Intriguingly, the same is true in patients with Tourette syndrome.  Using a softer form of swearing gives them much less relief from the urge to tic, like rubbing an itch instead of scratching it."

            Byrnes reports that those doing the research can't answer the question of why swearing acts as a painkiller.  There is no doubt that it does, however.  Now, at least, I am justified in howling an obscenity when I drop something heavy on my toe.

* * *

The Defense Advanced Research Projects Agency (DARPA) is "responsible for the development of emerging technologies for use by the military."  It has also been called the "mad science" division of the Department of Defense.  (If I recall correctly, DARPA is basically responsible for the Internet.)  I know that a number of faculty members at the University of Minnesota have received grants from DARPA, sometimes on pretty esoteric research.  DARPA apparently also defines "technologies" quite broadly, given a recent request for proposals it issued.  In the words of Adam Rogers, writing for Wired, DARPA is "trying to build a real, live, bullshit detector. . . .  The quite serious call for proposals Russell [an anthropologist and DARPA program manager] just sent out on Darpa stationery asks people—anyone! Even you!—for ways to determine what findings from the social and behavioral sciences are actually, you know, true.  Or in his construction:  'credible.'"

You ask why DARPA seeks findings from the social sciences, not fields that most would consider "technology."  "They want to understand how collective identity works, or why some groups (and nations) are stable and some fall apart. The military would like to get a better handle on how humans team up with machines before the machines get smarter and more get deployed.  How does radicalization work, especially online?  Why do people cooperate sometimes and compete at others?  All these questions have two things in common:  They are super-important to national security, and no one knows the answer."  In other words, which findings could reasonable provide the basis for Department of Defense policy or action?

            A biologist friend of mine identified a major headache for the social sciences.  "I am always a bit wary of fields which add the word 'science' to their subject.  Take for example economic 'science,' social 'science' or educational 'science.'  These fields are not close to being a true science because nearly all of their research output is correlative rather than causal.  Hypotheses are never directly tested and results tend to support a preconceived viewpoint on the part of the researchers." 

Social scientists—political scientists, psychologists, sociologists, economists, anthropologists—could test hypotheses by conducting experiments.  Many such experiments, however, would be illegal or unethical or both.  (Two famous psychology experiments could not be repeated today.  Milgram had subjects deliver (fake) electric shocks; Zimbardo had prisoners and guards.  In both cases, the research participants were extremely stressed by the experiments.)  I think it's probably a little harsh to say that the social sciences are not science.  They clearly are not scientists in the biology-chemistry-physics sense of the term.  (Psychology falls in between; it does conduct experiments.  For the most part, economics, political science, anthropology, sociology, and so on do not, at least not at the level of general society.)  But the social sciences, including psychology, use highly sophisticated statistical techniques to tease out "truths" from mounds of data.  Whether the "results tend to support a preconceived viewpoint" is an open question, in my view.  In some fields, some of the time, surely.  But I don't have the sense, from reading in the social sciences and having a lot of friends in the social sciences, that there's a pattern of effort to interpret (or even bias) results in one direction or another.  Most social science research I'm aware of tries to confirm or rebut a hypothesis.

I wouldn't say that DARPA is wasting its money.  Taking action on the basis of social science results—which are frequently more tentative than those in the biological and physical sciences—is certainly better than going on what your grandma or your neighbor thought.

* * *

            I recently sent to Kathy and Elliott a link to an article describing the apparent relationship between sugar and Alzheimer's, published in Diabetology, following a study at Imperial College London.

A longitudinal study . . . followed 5,189 people over 10 years and found that people with high blood sugar had a faster rate of cognitive decline than those with normal blood sugar—whether or not their blood-sugar level technically made them diabetic.  In other words, the higher the blood sugar, the faster the cognitive decline.

            Another researcher, at the Mayo Clinic,

broke nearly 1,000 people down into four groups based on how much of their diet came from carbohydrates.  The group that ate the most carbs had an 80 percent higher chance of developing mild cognitive impairment—a pit stop on the way to dementia—than those who ate the smallest amount of carbs.  People with mild cognitive impairment, or MCI, can dress and feed themselves, but they have trouble with more complex tasks.

            The article prompted Elliott to write back to me.  "I've been hearing a lot recently about sugar--and carbs in general--contributing significantly to the body's inflammation response (the article briefly references that as well), which a lot of doctors and physicians will tell you is the fundamental cause of the majority of illnesses and diseases in one way or another."

            I asked Elliott what he thought one should eat. 

It seems like the ideal diet consists entirely of meat and non-starch vegetables.  Maybe some blueberries.  Pretty much what we would have found or killed ten thousand years ago.  That's what our bodies are adapted to eating.  Makes sense.  When you have a traditional "balanced" diet, your body stores fat and burns carbs because they're more efficient.  But if you put yourself in a state of ketosis by denying carbs entirely, your body becomes quite good at burning fat for energy, which means you can happily eat butter and cheese.

            This is the ketogenic diet, because the low level of carb intake leads to ketosis, in which condition the body is burning rather than carbs.  Developed at the Mayo Clinic in 1924 to treat epilepsy (for which it is no longer used, replaced with drugs), "the classic ketogenic diet incorporates a very high fat ratio compared to carbohydrates, with a moderate to small amount of protein.  In fact carbohydrates are kept extremely low, while fats are eaten in much larger quantities than most people are used to.  As high-carbohydrate food sources are eliminated from the diet, natural fat sources take their place."

Elliott said he'd been reading about the ketogenic diet.  "Not a lot of peer reviewed stuff on the subject yet because it's only become a widespread concept very recently. But all the short term results are excellent, as are the handful of small experiments in using it to treat some chronic physiological conditions.  A lot of professional athletes and fighters/boxers are starting to adopt it as well, and you know those people and their teams are always watching the cutting edge of nutritional research to find any advantage."  I protested that I still like potatoes.  Elliott assured me I could still have my potatoes, but that there should be far fewer carbs in our diets.  He added that the "problem is [that] for regular people without a dietician it's really hard to have a proper ketogenic diet and a lot of people who try by following internet advice end up either failing or malnourished in one way or another."

            I asked a faculty friend in the Medical School about the ketogenic diet.  I received a long but contrary, lucid, and I thought sensible response.

This is an old idea that has been around for a long time now—the basis of the low carb craze.  It is a particularly effective way to lose weight— particularly fat around the belly for some reason.  The problems are many however - one is maintaining appropriate nutrition.  Just logically, any diet that tells you not to eat fruit or even carrots must have something wrong with it.  Also, there is no way to cheat and get the benefits—thus there is high risk of people falling off it.  For example, you're all in with the high fat/ meat diet, but then decide you want a piece of whole grain toast to go with your eggs and bacon—bam, you're off the diet and the ketosis benefit is gone and you are setting people up for serious weight gain. . . .  You can't tell me that eating all that saturated fat and often processed food (bacon, cheese) doesn't have bad effects.  I have read the Alzheimer's study they did that showed improved memory in patients on the strict diet—that may be useful.  Because ketosis is a powerful chemical effect, so it makes sense that it has neurologic implications that could be harnessed for some benefit.  Again though, maintenance is very hard. I did this diet as a part of a group of people about  a year ago—mainly to see what it was like.  We were restricted to 50g/d which is a typical limit.  It was so hard.  Easy for the first couple days, but then you start craving bread and fruit (not to mention wine!).  It also makes people super crabby.  Even if you're not hungry, it does affect your personality, your GI system, your breath.

I do contend however, that refined sugar and highly processed foods, including, sadly, white flour, are evil.  There is a lot of evidence that sugar can alter your brain and withdrawing from it is real!  I think (and this is not a novel idea) that the more you eat real food, the better you are—yes, maintain high protein (chicken, fish—watch the bacon) lots of veggies (and sauté them with a little olive oil or whatever makes them taste good) and eat some fruit every day to diversify your diet. We just have to glance through history to see how bad our diet fads are in retrospect.

The Mayo Clinic website concurs.

Severely restricting carbohydrates to less than 0.7 ounces (20 grams) a day can result in a process called ketosis.  Ketosis occurs when you don't have enough sugar (glucose) for energy, so your body breaks down stored fat, causing ketones to build up in your body.  Side effects from ketosis can include nausea, headache, mental and physical fatigue, and bad breath.

It's not clear what kind of possible long-term health risks a low-carb diet may pose because most research studies have lasted less than a year.  Some health experts believe that if you eat large amounts of fat and protein from animal sources, your risk of heart disease or certain cancers may actually increase.

            I have learned in recent years to pay attention to some of what Elliott is paying attention to, but in this case I told him I didn't think much of a ketogenic diet.  It's not a counter argument to the ketogenic diet, to be sure, but I still like potatoes and I will eat fruit.  And drink wine (and perhaps scotch).  The news about food intake and health has been so voluminous and mixed in recent years that I take everything with a grain of salt (but not sugar  😊 ).  It does appear, however, that the evidence against refined sugar is piling up.  Fortunately for me, I've never much cared for sweets in any form, so I should stay sane for a few years longer.  I think Elliott doesn't intend to try achieving the ketogenic diet, to his credit.  He agrees that most people couldn't follow the diet.

            On the topic of food, I recently made my own alfredo sauce to go with some pasta.  1 pint heavy cream, 1 stick butter, half a package of cream cheese, and 1 cup grated parmesan, all melted/whisked together.  Plus a few spices.  I guess it would be fine if you were on a strict ketogenic diet, but for the rest of us it's guaranteed to produce a cardiac event.  Tasted great, however.  I'm not sure Epicurus would have approved.

Gary




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